A Vanished Association Between Proton Pump Inhibitors and Clostridioides Difficile Infection After Minimizing Bias
Bin Wu, Zhiyao He, Ting Xu · 2025
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Description
Bin Wu, Zhiyao He, and Ting Xu re-ran a drug safety check in 2025 on acid drugs and a grave gut infection. Acid blockers change gut germs, and past reports tied them to higher risk of the infection, which is driven by a hardy germ. The team read two decades of harm reports sent to the United States drug agency, near a quarter million tied to acid drugs. They then stripped out a known skew step by step.
At first the link looked strong, with five acid drugs flagged. Once reports that also held germ drugs were cut, the signal shrank by a lot. With more cuts, one drug kept a faint flag. Split by age, the signal died in all groups once germ drugs were held apart. The link was a mirage of mixed data, they argue.
Catalog record
| CREATOR | Bin Wu, Zhiyao He, Ting Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |