Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells
Párástu Oskoei, Rúben Afonso, Verónica Bastos, João Nogueira, Lisa-Marie Keller, Elina Andresen, Maysoon I. Saleh, Bastian Rühle, Ute Resch-Genger, Ana L. Daniel-da-Silva, Helena Oliveira · 2025
Read Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells by Párástu Oskoei, Rúben Afonso, Verónica Bastos, João Nogueira, Lisa-Marie Keller, Elina Andresen, Maysoon I. Saleh, Bastian Rühle, Ute Resch-Genger, Ana L. Daniel-da-Silva, Helena Oliveira (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12787096.txt.
Description
Parastu Oskoei and co-authors build light-converting nanoparticles that carry a cancer drug to melanoma cells, in a 2025 study. Melanoma is among the most aggressive skin cancers, and standard therapy has clear limits. The particles are coated with porous silica and tagged with folic acid to home in on tumour cells.
The drug loads into the porous coat with high efficiency and leaks out faster in acid, mimicking tumour surroundings. Blank carriers proved gentle to cells, while loaded ones killed melanoma cells from four lines in a dose-linked way. Treated cells stalled at a late growth phase, confirming the anti-growth effect. The authors present the platform as a targeted delivery candidate worth animal testing.
Catalog record
| CREATOR | Párástu Oskoei, Rúben Afonso, Verónica Bastos, João Nogueira, Lisa-Marie Keller, Elina Andresen, Maysoon I. Saleh, Bastian Rühle, Ute Resch-Genger, Ana L. Daniel-da-Silva, Helena Oliveira |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |