Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value
Denisa Mădălina Viezuină, Irina (Mușa) Burlacu, Andrei Greșiță, Irina-Mihaela Matache, Elena-Anca Târtea, Mădălina Iuliana Mușat, Manuel-Ovidiu Amzoiu, Bogdan Cătălin, Veronica Sfredel, Smaranda Ioana Mitran · 2025
Read Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value by Denisa Mădălina Viezuină, Irina (Mușa) Burlacu, Andrei Greșiță, Irina-Mihaela Matache, Elena-Anca Târtea, Mădălina Iuliana Mușat, Manuel-Ovidiu Amzoiu, Bogdan Cătălin, Veronica Sfredel, Smaranda Ioana Mitran (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12787077.txt.
Description
Denisa Mădălina Viezuină and co-authors review how to judge healing of the sciatic nerve, the large nerve of the leg, in animal studies of new therapies. Such injuries often heal poorly in people, and many lab advances never reach patients. Part of the problem is that studies measure recovery in ways that do not match the stage of healing.
The review maps tests onto four phases of repair, from the first days through late regrowth. Tests include walking scores, balance tasks, nerve signal studies, and tissue measures. Each phase has its own biology, so the right test at the wrong time can mislead. The authors also survey emerging therapies and judge their promise for human care.
Catalog record
| CREATOR | Denisa Mădălina Viezuină, Irina (Mușa) Burlacu, Andrei Greșiță, Irina-Mihaela Matache, Elena-Anca Târtea, Mădălina Iuliana Mușat, Manuel-Ovidiu Amzoiu, Bogdan Cătălin, Veronica Sfredel, Smaranda Ioana Mitran |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |