LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer
Ying Wu, Wenda Zhang, Shanshan Jiang, Sailong Liu, Jing Su, Liankun Sun · 2025
Read LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer by Ying Wu, Wenda Zhang, Shanshan Jiang, Sailong Liu, Jing Su, Liankun Sun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12787023.txt.
Description
Ying Wu and co-authors link in 2025 a copper driven form of cell death in ovarian cancer to the cell's power plants and to one guard protein. A copper carrying drug sparks this death by striking fat tagged parts of a core energy cycle. The team treated ovarian cancer cells with the drug and tracked power plant stress, copper handling proteins, and death markers.
Stress signals and a death marker rose, while a protein needed to build the fat tag fell. Several copper movers and parts of the breathing chain's last complex also fell, along with the guard protein. Blocking that guard changed the death course. The authors name it as a key factor and a possible lever for therapy.
Catalog record
| CREATOR | Ying Wu, Wenda Zhang, Shanshan Jiang, Sailong Liu, Jing Su, Liankun Sun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |