Newly Synthesized Telmisartan–Amino Acid Conjugates Exhibit Enhanced Cytotoxic Effects in Malignant Melanoma Cells
Dragana Vukadinović, Ana Damjanović, Miodrag Vuković, Olivera Čudina, Jelena Grahovac, Vladimir Dobričić · 2025
Read Newly Synthesized Telmisartan–Amino Acid Conjugates Exhibit Enhanced Cytotoxic Effects in Malignant Melanoma Cells by Dragana Vukadinović, Ana Damjanović, Miodrag Vuković, Olivera Čudina, Jelena Grahovac, Vladimir Dobričić (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12787000.txt.
Description
Dragana Vukadinović and colleagues re-engineer a blood pressure drug to kill melanoma while sparing blood pressure, in this study from twenty twenty-five. Telmisartan blocks a hormone receptor and, as a side talent, kills melanoma cells with a common mutation. Its pressure-lowering action, though, bars use in patients with normal pressure.
The team stitched amino acids onto the drug, making eight conjugates designed to slip into cells better and grip the hormone receptor less. Three stood out against two melanoma lines, including one resistant to a standard targeted drug. The best beat the parent drug on strength and on selectivity, hurting cancer cells far more than normal ones. None of the three blocked the hormone signal, as intended. They also entered cells in greater amounts and stalled the cell cycle while wrecking mitochondria. Animal tests are the next gate for these candidates.
Catalog record
| CREATOR | Dragana Vukadinović, Ana Damjanović, Miodrag Vuković, Olivera Čudina, Jelena Grahovac, Vladimir Dobričić |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |