High-Resolution 1H NMR Investigation of the Speciation Status of Nickel(II) and Copper(II) Ions in a Cell Culture Medium: Relevance to Their Toxicological Actions
Deepinder K. Kalra, Kayleigh Hunwin, Katie Hewitt, Olivia Steel, Martin Grootveld · 2025
Read High-Resolution 1H NMR Investigation of the Speciation Status of Nickel(II) and Copper(II) Ions in a Cell Culture Medium: Relevance to Their Toxicological Actions by Deepinder K. Kalra, Kayleigh Hunwin, Katie Hewitt, Olivia Steel, Martin Grootveld (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12786676.txt.
Description
Deepinder Kalra and co-authors use NMR scans to learn what form nickel and copper ions take inside a common cell culture fluid. Their 2025 study cares because the ions' chemical dress, called speciation, decides how cells take them up and whether they help or harm. Both metals are needed in traces as enzyme helpers, yet both turn toxic in excess.
The fluid, a standard growth medium, is full of biomolecules eager to bind metals. Proton NMR, a gentle method that leaves the sample intact, watched those bindings form. The work grounds later toxicity claims in the actual chemistry cells meet, rather than in the dose printed on the bottle.
Catalog record
| CREATOR | Deepinder K. Kalra, Kayleigh Hunwin, Katie Hewitt, Olivia Steel, Martin Grootveld |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |