Effectiveness of Intranasal Esketamine on Suicidal Ideation and Depressive Symptoms in Patients with Treatment-Resistant Depression: A Longitudinal Study
Matteo Leonardi, Alice Frediani, Maria Chiara Angeletti, Monica Biseo, Giada Versaci, Michele Castiglioni, Miriam Olivola, Matteo Vismara, Alberto Varinelli, Monica Bosi, Beatrice Benatti, Natascia Brondino, Bernardo Maria Dell’osso · 2025
Read Effectiveness of Intranasal Esketamine on Suicidal Ideation and Depressive Symptoms in Patients with Treatment-Resistant Depression: A Longitudinal Study by Matteo Leonardi, Alice Frediani, Maria Chiara Angeletti, Monica Biseo, Giada Versaci, Michele Castiglioni, Miriam Olivola, Matteo Vismara, Alberto Varinelli, Monica Bosi, Beatrice Benatti, Natascia Brondino, Bernardo Maria Dell’osso (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12786460.txt.
Description
Matteo Leonardi and twelve co-authors track intranasal esketamine in patients with treatment resistant depression in this 2025 paper. Eighty patients were scored at intake and five later points over six months. Suicidal thinking fell fast: scores halved within a week and nearly vanished by six months. Depression scores dropped from about thirty-two to about ten over the same span. Over two thirds of patients answered on suicidal thinking within the first week. The depression response rate climbed to about sixty-three percent by the end.
Only one factor predicted early response: men answered less often than women. No other intake trait mattered. The drug's speed is its selling point in a crisis, where weeks of waiting carry risk. Real world data like these are still scarce since approval is recent. The authors say the results support esketamine as a rapid tool against suicidal thinking in resistant depression.
Catalog record
| CREATOR | Matteo Leonardi, Alice Frediani, Maria Chiara Angeletti, Monica Biseo, Giada Versaci, Michele Castiglioni, Miriam Olivola, Matteo Vismara, Alberto Varinelli, Monica Bosi, Beatrice Benatti, Natascia Brondino, Bernardo Maria Dell’osso |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |