Integrated Network Toxicology and Metabolomics Reveal the Ovarian Toxicity Mechanisms of Chronic Carbofuran Exposure in Female Mice
Di Liang, Hongyu Su, Xian Ju · 2025
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Description
Di Liang, Hongyu Su, and Xian Ju dissect how the pesticide carbofuran damages ovaries, combining computer toxicology with metabolic profiling in mice. Female mice dosed daily for forty-five days showed harm that grew with dose: low follicle reserves, more dying follicles, abnormal hormone levels, and ovarian tissue in disarray.
Network analysis named thirty-eight shared toxicity targets, with four core proteins showing strong binding. Metabolomics found upset amino-acid pathways. The joint picture points to hormone disruption, oxidative stress, inflammation, and metabolic systems out of balance acting together. The authors offer the joint approach as a template for judging risks from chemicals around us to breeding health.
Catalog record
| CREATOR | Di Liang, Hongyu Su, Xian Ju |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |