Pilot Proteomic Analysis of Urinary Extracellular Vesicles Supports the “Toxic Urine Hypothesis” as a Vicious Cycle in Refractory IC/BPS Pathogenesis
Man-Jung Hung, Evelyn Yang, Tsung-Ho Ying, Peng-Ju Chien, Ying-Ting Huang, Wen-Wei Chang · 2025
Read Pilot Proteomic Analysis of Urinary Extracellular Vesicles Supports the “Toxic Urine Hypothesis” as a Vicious Cycle in Refractory IC/BPS Pathogenesis by Man-Jung Hung, Evelyn Yang, Tsung-Ho Ying, Peng-Ju Chien, Ying-Ting Huang, Wen-Wei Chang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12786074.txt.
Description
Man-Jung Hung and five co-authors read proteins in urine vesicles from women with hard-to-treat bladder pain. Their paper is from two thousand twenty-five. The ill, called IC/BPS, can keep its signs in spite of many cares. A claim in the field holds that toxic urine seeps through a weak bladder wall, sparks swelling, and weakens the wall more, in a loop.
Vesicles from patients hold a set of proteins shifted from those of healthy women. Acute swelling marks are low, while repair and metabolism paths are high. Patient vesicles switch on a key swelling path in bladder cells in the lab. The finds back the toxic urine claim.
Catalog record
| CREATOR | Man-Jung Hung, Evelyn Yang, Tsung-Ho Ying, Peng-Ju Chien, Ying-Ting Huang, Wen-Wei Chang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |