Mesenchymal Stem Cell Secretome for Cardiac Regeneration: Opportunity for Cell-Free Therapy
Paulina Piotrowska, Honorata Kraskiewicz, Aleksandra Klimczak · 2025
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Description
Paulina Piotrowska, Honorata Kraskiewicz, and Aleksandra Klimczak review using stem cell secretions, rather than the cells themselves, to heal heart muscle, in a 2025 article. Mesenchymal stem cells help injured hearts mainly by what they release, not by becoming heart tissue. Harvesting that release, the secretome, could give the benefit without transplanting living cells.
The review gathers studies that applied secretomes from various stem cell sources after heart attacks. Attention centers on the protein cargo that may drive repair of heart muscle cells. Priming the parent cells, by stress or culture tricks, can tailor the mixture toward cardiac healing. Early animal findings are summarized as encouraging. The authors frame cell-free therapy as safer and easier to standardize than cell transplants. Clinical proof, they note, still lies ahead.
Catalog record
| CREATOR | Paulina Piotrowska, Honorata Kraskiewicz, Aleksandra Klimczak |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |