Colon Organoids as Experimental Models to Study the Effect of Micro-Nanoparticles as a Driver of Early-Onset Colon Cancer
Zahra Heydari, Gobinda Sarkar, Lauren Helgeson, Estela Mariel Cruz Garcia, Alexandra Ros, Khashayarsha Khazaie, Lisa Boardman · 2025
Read Colon Organoids as Experimental Models to Study the Effect of Micro-Nanoparticles as a Driver of Early-Onset Colon Cancer by Zahra Heydari, Gobinda Sarkar, Lauren Helgeson, Estela Mariel Cruz Garcia, Alexandra Ros, Khashayarsha Khazaie, Lisa Boardman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12786032.txt.
Description
Zahra Heydari and co-authors propose, in a 2025 paper, using lab-grown colon tissue to test whether tiny plastic particles help drive early-onset colon cancer. Cancer of the colon before age fifty is rising worldwide for unknown reasons. Plastic particles swallowed with food and water are one suspect.
These particles can cross the gut wall and meet epithelial and immune cells directly. Inside tissue, they may spark oxidative stress, tear membranes, and stir inflammation and genome instability. Organoids grown from patients mimic the colon closely and scale well for experiments. The paper lays out how such models can test the plastic hypothesis cleanly. Finding a preventable driver would matter for a cancer striking ever younger adults.
Catalog record
| CREATOR | Zahra Heydari, Gobinda Sarkar, Lauren Helgeson, Estela Mariel Cruz Garcia, Alexandra Ros, Khashayarsha Khazaie, Lisa Boardman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |