The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes
Renata Voltolini Velho, Julia Hannah Freitag, Arie Maeve Brueckner, Laura Thalmeier, Jonathan Pohl, Sylvia Mechsner · 2025
Read The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes by Renata Voltolini Velho, Julia Hannah Freitag, Arie Maeve Brueckner, Laura Thalmeier, Jonathan Pohl, Sylvia Mechsner (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785993.txt.
Description
Renata Voltolini Velho and co-authors mapped histamine signaling across endometriosis lesion types in a 2025 study. Endometriosis pain mixes several kinds: direct tissue pain, nerve pain, and pain driven by inflammation near nerves. Histamine, best known from allergy, has emerged as a link between inflammation and nerve sensitization.
The team counted the enzyme that makes it, all four of its receptors, and related cytokines in lesion subtypes. A map by subtype matters because lesions behave in unlike ways and may need unlike drugs. If it drives pain in some types, antihistamine and receptor drugs now in use could be used for this too. The study builds the molecular case lesion by lesion.
Catalog record
| CREATOR | Renata Voltolini Velho, Julia Hannah Freitag, Arie Maeve Brueckner, Laura Thalmeier, Jonathan Pohl, Sylvia Mechsner |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |