Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway
Qian Zeng, Min-Lin Liao, Yu-Yang Luo, Shuang Li, Gao You, Chong-Mei Huang, Min-Hui Liu, Wei Liu, Si-Yuan Tang · 2025
Read Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway by Qian Zeng, Min-Lin Liao, Yu-Yang Luo, Shuang Li, Gao You, Chong-Mei Huang, Min-Hui Liu, Wei Liu, Si-Yuan Tang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785948.txt.
Description
Zeng and co-authors report a 2025 study on a plant compound that may fight lung scarring. Idiopathic pulmonary fibrosis stiffens the lungs over time, and good drug options are lacking. Lathyrol comes from a traditional Chinese medicinal plant and has wide effects in the body. The team tested it in mice with lung scarring and in lab fibroblast cells.
In mice, the compound eased lung damage, and a blocker drug erased that benefit. In cells, it stopped fibroblasts from turning into scar-forming cells. Gene scans pointed to one pathway, driven by a switch called PPARγ, that quiets a growth signal. The authors trace how the switch removes a key messenger protein.
Catalog record
| CREATOR | Qian Zeng, Min-Lin Liao, Yu-Yang Luo, Shuang Li, Gao You, Chong-Mei Huang, Min-Hui Liu, Wei Liu, Si-Yuan Tang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |