The Need for a Systems Biology Approach in Cancer Explained
Hehuan Zhu, Xi Zhang, Ehsan Nazemalhosseini-Mojarad, Jessica Roelands, Lysanne D. A. N. de Muynck, Cor J. Ravensbergen, Rachel Hoorntje, Imke Stouten, Marianne Hokland, Alexander L. Vahrmeijer, Rob A. E. M. Tollenaar, Edwin Koster, Peter J. K. Kuppen · 2025
Read The Need for a Systems Biology Approach in Cancer Explained by Hehuan Zhu, Xi Zhang, Ehsan Nazemalhosseini-Mojarad, Jessica Roelands, Lysanne D. A. N. de Muynck, Cor J. Ravensbergen, Rachel Hoorntje, Imke Stouten, Marianne Hokland, Alexander L. Vahrmeijer, Rob A. E. M. Tollenaar, Edwin Koster, Peter J. K. Kuppen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785932.txt.
Description
Hehuan Zhu and co-authors argue in 2025 that cancer research needs a systems view, not just a parts list. Past work cut tumors down to single genes and changes. That path gave real wins, such as new immune drugs. Yet a gene change does not map one to one onto cancer. Only some patients gain from those drugs.
The review says a tumor's behavior grows out of how its parts work together. Cell types, signals, and blocks and boosts in a web all shape the outcome. Gene reading tools made this whole view possible. The authors set out what the systems path can and cannot do. They offer a frame that joins causes at low and high levels to explain tumor growth.
Catalog record
| CREATOR | Hehuan Zhu, Xi Zhang, Ehsan Nazemalhosseini-Mojarad, Jessica Roelands, Lysanne D. A. N. de Muynck, Cor J. Ravensbergen, Rachel Hoorntje, Imke Stouten, Marianne Hokland, Alexander L. Vahrmeijer, Rob A. E. M. Tollenaar, Edwin Koster, Peter J. K. Kuppen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |