Low Expression of UBE2Z, a Target Protein of miR-500a, Is Associated with Poor Prognosis in Triple-Negative Breast Cancer
Donghyun Kim, Song-Yi Choi · 2025
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Description
Donghyun Kim and Song-Yi Choi published a breast cancer study in twenty twenty-five on a small RNA and its target protein. Their focus was triple-negative disease, the subtype with the worst prognosis and no targeted therapy. MicroRNA profiles from relapsing versus non-relapsing patients' tumors were compared to find prognostic signals.
Three microRNAs were raised and two lowered in tumors that came back. Bioinformatics traced their target proteins into cancer signaling pathways. One target stood out: UBE2Z, a ubiquitin-system enzyme controlled by miR-500a. Low UBE2Z levels in tumors were associated with poor patient outcomes. The pair becomes a candidate prognostic marker and a possible therapeutic lever in a cancer that badly needs both.
Catalog record
| CREATOR | Donghyun Kim, Song-Yi Choi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |