Salts of Antifolate Pyrimethamine with Isomeric Aminobenzoic Acids: Exploring Packing Interactions and Pre-Crystallization Aggregation
Karolina Cichocka, Magdalena Zimnicka, Karolina Kędra, Arkadiusz Gajek, Magdalena Ceborska · 2025
Read Salts of Antifolate Pyrimethamine with Isomeric Aminobenzoic Acids: Exploring Packing Interactions and Pre-Crystallization Aggregation by Karolina Cichocka, Magdalena Zimnicka, Karolina Kędra, Arkadiusz Gajek, Magdalena Ceborska (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785875.txt.
Description
Five authors, led by Karolina Cichocka, grow in 2025 new salt forms of an antiparasite drug by pairing it with three near twin acids. The drug, pyrimethamine, treats protozoan infections and often needs better solid forms. Each acid differs only in where its amino group sits on the ring.
Solution growing yielded three solvated salts. X-ray, infrared, powder, and heat methods pinned down their structures and stability. Spray mass readings of the pre growing liquids caught loose clusters forming early. The work links those early clusters to the final packing, a clue for designing drug salts on purpose.
Catalog record
| CREATOR | Karolina Cichocka, Magdalena Zimnicka, Karolina Kędra, Arkadiusz Gajek, Magdalena Ceborska |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |