Triterpenoids CDDO and CDDO-EA Inhibit the Replication of Hepatitis B Virus by Modulating Nucleocapsid Assembly
Qiang Gao, Ge Yang, Ya Wang, Lu Yang, Jin Hu, Huiqiang Wang, Haiyan Yan, Kun Wang, Shuo Wu, Yuhuan Li, Jiandong Jiang · 2025
Read Triterpenoids CDDO and CDDO-EA Inhibit the Replication of Hepatitis B Virus by Modulating Nucleocapsid Assembly by Qiang Gao, Ge Yang, Ya Wang, Lu Yang, Jin Hu, Huiqiang Wang, Haiyan Yan, Kun Wang, Shuo Wu, Yuhuan Li, Jiandong Jiang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785804.txt.
Description
Qiang Gao and a team of co-authors find two plant-derived compounds that block hepatitis B virus by jamming its shell building. Their study appeared in twenty twenty-five. Chronic hepatitis B still lacks a cure, and current drugs only hold the virus down.
The compounds, CDDO and its ethyl amide form, cut viral DNA copying sharply. They left the virus's RNA template and shell protein amounts near normal. Yet packaged RNA inside and outside cells fell steeply with dose. Gel tests showed the shells formed empty instead. The compounds change the shell protein's chemical tagging and bind the seams where shell units meet. Paired with a standard drug, one compound worked even better. Development as a lead drug is warranted.
Catalog record
| CREATOR | Qiang Gao, Ge Yang, Ya Wang, Lu Yang, Jin Hu, Huiqiang Wang, Haiyan Yan, Kun Wang, Shuo Wu, Yuhuan Li, Jiandong Jiang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |