Novel ACE-Inhibitory Peptides from Royal Jelly Proteins: Comprehensive Screening, Mechanistic Insights, and Endothelial Protection
Wanyu Yang, Xinyu Zou, Tianrong Zhang, Qingqing Liu, Ziyan Liu, Fan Li, Yuhong Luo, Yiwen Wang, Zhijun Qiu, Bin Zhang · 2025
Read Novel ACE-Inhibitory Peptides from Royal Jelly Proteins: Comprehensive Screening, Mechanistic Insights, and Endothelial Protection by Wanyu Yang, Xinyu Zou, Tianrong Zhang, Qingqing Liu, Ziyan Liu, Fan Li, Yuhong Luo, Yiwen Wang, Zhijun Qiu, Bin Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785803.txt.
Description
Wanyu Yang and co-authors hunt for blood pressure lowering peptides in royal jelly proteins in a 2025 study. Royal jelly is the rich food bees feed to queens, and its proteins may hide fragments that block a pressure-raising enzyme.
Computer digestion of three main jelly proteins yielded over a thousand candidate fragments. Screening for activity, safety, and body handling cut the list to a short set for docking tests. Two peptides blocked the enzyme in lab tests, one as a mixed-type blocker. Cell tests showed the lead peptide guarded vessel lining cells and eased stress signals. The authors pitch it as a candidate for natural pressure aids or functional foods.
Catalog record
| CREATOR | Wanyu Yang, Xinyu Zou, Tianrong Zhang, Qingqing Liu, Ziyan Liu, Fan Li, Yuhong Luo, Yiwen Wang, Zhijun Qiu, Bin Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |