Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to Two Different Chemorepellents
Salman Zahir Uddin, Ramesh Rijal, Darrell Pilling, Richard H. Gomer · 2025
Read Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to Two Different Chemorepellents by Salman Zahir Uddin, Ramesh Rijal, Darrell Pilling, Richard H. Gomer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785797.txt.
Description
Salman Uddin and co-authors map in 2025 how a social amoeba's cells answer two different keep away signals at the level of proteins and their phosphate switches. Dictyostelium cells flee both a secreted protein called AprA and simple polyphosphate, but whether the two alarms ring the same circuitry was unknown.
Mass spectrometry censused the shifts. Each signal moved hundreds of proteins, yet the overlap was small, only a few dozen moving together and a handful pushed in opposite directions. Many targets sat in RNA handling and the ribosome, an unexpected address for a movement response. Phosphate switches flipped on motility proteins as expected. Two shared switches stood out: both signals dimmed the same pair of regulators, and mutant cells missing either one ignored both repellents. The verdict is two partly separate escape programs that converge on a few common nodes, which the authors nominate as the core of chemorepulsion.
Catalog record
| CREATOR | Salman Zahir Uddin, Ramesh Rijal, Darrell Pilling, Richard H. Gomer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |