Lymphatic Endothelial Cells and Organ-Associated Lymphangiogenesis in Tumor Microenvironment
Rui-Cheng Ji · 2025
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Description
Rui-Cheng Ji reviews how lymphatic vessels and their lining cells shape the tumor environment, in a 2025 article. Lymph vessels vary by organ and adapt to local conditions. Their lining cells differ in character across the body. New vessel growth in tumors, called lymphangiogenesis, marks cancer progression. It also feeds treatment resistance. The vessels carry a dual effect. They can spread cancer, yet they also move immune cells.
The review covers vessel remodeling in tumors. It traces talks among lining cells, immune cells, and cancer cells. Faulty vessel architecture harms organ-specific function. Blocking new growth is a route to slow lymph spread. Immune checkpoint drugs may add value there. The author gathers the evidence for targeting this system. Understanding organ differences is presented as essential. A single anti-lymph strategy may not fit all cancers.
Catalog record
| CREATOR | Rui-Cheng Ji |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |