Topical Administration of Sitagliptin Prevents Retinal Neurodegeneration in a Model of Glaucoma Induced by Dexamethasone
Patricia Bogdanov, Anna Duarri, David Sabater, María José Canz, Helena Isla-Magrané, Hugo Ramos, Anna Deàs-Just, Rafael Simó, Cristina Hernández · 2025
Read Topical Administration of Sitagliptin Prevents Retinal Neurodegeneration in a Model of Glaucoma Induced by Dexamethasone by Patricia Bogdanov, Anna Duarri, David Sabater, María José Canz, Helena Isla-Magrané, Hugo Ramos, Anna Deàs-Just, Rafael Simó, Cristina Hernández (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785737.txt.
Description
Patricia Bogdanov and eight co-authors report a 2025 mouse study on eye drops that may guard the retina in glaucoma. Glaucoma kills the nerve cells that carry sight, and high eye pressure is only part of the story. A diabetes drug, sitagliptin, had already guarded retinas in diabetic mice.
The team raised glaucoma in mice with weekly steroid shots for five weeks. Half got the drug as drops from day 14 to day 35. Steroid alone wiped out many nerve cells and fibers. The drops blocked that loss without changing eye pressure, which points to a direct guard effect on the nerve cells.
Catalog record
| CREATOR | Patricia Bogdanov, Anna Duarri, David Sabater, María José Canz, Helena Isla-Magrané, Hugo Ramos, Anna Deàs-Just, Rafael Simó, Cristina Hernández |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |