Oral Nano-Delivery of Crotoxin Modulates Experimental Ulcerative Colitis in a Mouse Model of Maximum Acute Inflammatory Response
Raquel Guedes de Oliveira Brito, Fernanda Narangeira de Araujo Neves, Larissa Ferreira de Almeida, Bruna Cristina Favoretto, Wafa Hanna Koury Cabrera, Nancy Starobinas, Jamile Macedo Garcia, Natália Coelho Couto de Azevedo Fernandes, José Luiz de Souza Lopes, Marcia Carvalho de Abreu Fantini, Pedro · 2025
Read Oral Nano-Delivery of Crotoxin Modulates Experimental Ulcerative Colitis in a Mouse Model of Maximum Acute Inflammatory Response by Raquel Guedes de Oliveira Brito, Fernanda Narangeira de Araujo Neves, Larissa Ferreira de Almeida, Bruna Cristina Favoretto, Wafa Hanna Koury Cabrera, Nancy Starobinas, Jamile Macedo Garcia, Natália Coelho Couto de Azevedo Fernandes, José Luiz de Souza Lopes, Marcia Carvalho de Abreu Fantini, Pedro (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785686.txt.
Description
Raquel de Oliveira Brito and co-authors tested in 2025 a snake venom part, delivered by mouth in tiny silica carriers, against bowel inflammation in mice. The venom part can ease pain and calm immune responses, but it is toxic on its own. Loading it into the silica lowers toxicity and protects it from digestion.
Detailed checks confirmed the venom part was well loaded into the carrier. Mice with a chemically triggered bowel disease got the complex at the start or on later days. After a week, disease scores fell by about half. Colon tissue also looked much healthier under the microscope, a first for this use.
Catalog record
| CREATOR | Raquel Guedes de Oliveira Brito, Fernanda Narangeira de Araujo Neves, Larissa Ferreira de Almeida, Bruna Cristina Favoretto, Wafa Hanna Koury Cabrera, Nancy Starobinas, Jamile Macedo Garcia, Natália Coelho Couto de Azevedo Fernandes, José Luiz de Souza Lopes, Marcia Carvalho de Abreu Fantini, Pedro |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |