Mitochondrial Transplantation Restores Immune Cell Metabolism in Sepsis: A Metabolomics Study
Tae Nyoung Chung, Se Rin Choi, Su-Hyun Kim, Choong Hwan Lee, Kyuseok Kim · 2025
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Description
Sepsis shuts down the power plants of immune cells, and transplanting fresh ones may restart them. Tae Nyoung Chung, Se Rin Choi, Su-Hyun Kim, Choong Hwan Lee, and Kyuseok Kim tested that rescue in rats in a 2025 study. Blood and spleen immune cells were read with a chemical profiling method. Groups covered healthy, septic, and transplant-treated animals.
Sepsis crushed key chemicals tied to amino acids, sugars, and fats in the immune cells. Transplant care pushed many of those chemicals back toward healthy levels. Core energy and building pathways switched back on in the treated group. Pattern tools split the three groups cleanly. The authors offer the data as direct proof that donated power plants reprogram immune chemistry.
Catalog record
| CREATOR | Tae Nyoung Chung, Se Rin Choi, Su-Hyun Kim, Choong Hwan Lee, Kyuseok Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |