Deletion of Glutamate Delta 1 Receptor Leads to Heterogeneous Transcription and Synaptic Gene Alterations Across Brain Regions
Jingguo Huang, Jiahao Liao, Xuanying Chen, Guiping Lin, Yangwangmu De, Huakun Shangguan, Wucheng Tao · 2025
Read Deletion of Glutamate Delta 1 Receptor Leads to Heterogeneous Transcription and Synaptic Gene Alterations Across Brain Regions by Jingguo Huang, Jiahao Liao, Xuanying Chen, Guiping Lin, Yangwangmu De, Huakun Shangguan, Wucheng Tao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785485.txt.
Description
Jingguo Huang and co-authors map what happens across the mouse brain when a certain glutamate receptor, GluD1, is missing, in a 2025 study. The receptor helps form and keep synapses and has been tied to hearing, cognition, and development disorders.
Mice without the receptor showed wide gene changes in four brain regions and in subregions of the hippocampus. The patterns differed by region, yet the changed genes everywhere clustered in synapse signaling paths. The receptor's partner network overlaps with risk genes for intellectual disability and autism. The work frames the receptor as a broad organizer of synapse genes, with effects that depend on place.
Catalog record
| CREATOR | Jingguo Huang, Jiahao Liao, Xuanying Chen, Guiping Lin, Yangwangmu De, Huakun Shangguan, Wucheng Tao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |