Large-Scale Multigenome-Wide Study Predicts the Existence of Transmembrane Phosphotransfer Proteins in Plant Multistep Phosphorelay Signaling Pathway
Sergey N. Lomin, Wolfram G. Brenner, Ekaterina M. Savelieva, Dmitry V. Arkhipov, Georgy A. Romanov · 2025
Read Large-Scale Multigenome-Wide Study Predicts the Existence of Transmembrane Phosphotransfer Proteins in Plant Multistep Phosphorelay Signaling Pathway by Sergey N. Lomin, Wolfram G. Brenner, Ekaterina M. Savelieva, Dmitry V. Arkhipov, Georgy A. Romanov (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785465.txt.
Description
Sergey Lomin and co-authors predict a hidden class of plant signaling proteins that sit in membranes rather than floating free. Plants relay hormone signals through a bucket-brigade of proteins that pass phosphate groups along, and the known carriers of one step in that chain were all soluble. Mining genomes across the plant tree, the team found 94 candidate relatives in 62 species, from mosses to flowering plants. Each carries a membrane anchor plus the conserved working motif of the family.
Family trees sorted the candidates into two groups matching known lineages, and gene activity data confirmed most are really produced, though quietly and perhaps only in certain tissues or moments. Computer models showed plausible folded shapes, and simulations supported the anchors' grip on membranes. The authors propose these anchored carriers tune the hormone pathway from the membrane, and they lay out mechanisms by which that tuning might work.
Catalog record
| CREATOR | Sergey N. Lomin, Wolfram G. Brenner, Ekaterina M. Savelieva, Dmitry V. Arkhipov, Georgy A. Romanov |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |