Integrated Assessment of the Cardiotoxic and Neurobehavioral Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Zebrafish Embryos
Ouwais Aljabasini, Niki Tagkalidou, Juliette Bedrossiantz, Eva Prats, Raul Lopez-Arnau, Demetrio Raldua · 2025
Read Integrated Assessment of the Cardiotoxic and Neurobehavioral Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Zebrafish Embryos by Ouwais Aljabasini, Niki Tagkalidou, Juliette Bedrossiantz, Eva Prats, Raul Lopez-Arnau, Demetrio Raldua (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785441.txt.
Description
Ouwais Aljabasini and co-authors dose zebrafish embryos with a designer stimulant to chart its harm to heart and behavior, in this 2025 study. MDPV, a synthetic cathinone with high abuse potential, is a potent stimulant whose effects on early development are barely known. Zebrafish embryos, transparent and fast-developing, make a sensitive test bed. Three-day-old embryos showed dose-dependent slowing of the heart and blockages between its chambers.
At the top doses the chambers fell out of sync entirely. Behavior and molecular readouts joined the heart measures in one integrated assessment. Designer drugs reach the street years before toxicology catches up; embryo screens like this one give regulators early, structured evidence of what a new compound does to a developing body.
Catalog record
| CREATOR | Ouwais Aljabasini, Niki Tagkalidou, Juliette Bedrossiantz, Eva Prats, Raul Lopez-Arnau, Demetrio Raldua |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |