Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis
Connie Di Raimo, Christopher A. McCulloch · 2025
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Description
Connie Di Raimo and Christopher McCulloch review two signals that may help control fibrosis, the build-up of stiff scar tissue in organs. Their 2025 review centers on collagen, the protein that piles up when cells called myofibroblasts make more of it than the body breaks down. One signal, known as cAMP, tends to slow that process. The other is a channel called TRPV4, which lets calcium into cells.
The two signals push against each other, since calcium flow can change cAMP levels inside the cell. Drugs that raise cAMP, or that block the channel, could help tissues clear excess collagen. The authors weigh the proof for using both routes to treat organ scarring.
Catalog record
| CREATOR | Connie Di Raimo, Christopher A. McCulloch |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |