PAI-1: A Key Signal at the Crossroads of Stem Cell Differentiation and Senescence
Jihan Ke, Youping Jiang, Zhiyong Cheng, Yulan Zhou, Jiaxu Lu, Bo Xu, Shouquan Yan, Jiafeng Wang · 2025
Read PAI-1: A Key Signal at the Crossroads of Stem Cell Differentiation and Senescence by Jihan Ke, Youping Jiang, Zhiyong Cheng, Yulan Zhou, Jiaxu Lu, Bo Xu, Shouquan Yan, Jiafeng Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785347.txt.
Description
Jihan Ke and co-authors review a clot-control protein that also steers stem cell fate and cell aging, in work from two thousand twenty-five. The protein blocks the system that dissolves clots, its classic job. Fresh work ties it to fibrosis, clotting disorders, and tumor growth as well.
The review builds a signaling network centered on the protein for cell fate choices. It then weaves that network into known aging pathways. The two processes, choosing a fate and growing old, talk through this protein. The authors frame it as a drug target for chronic diseases that mix both threads.
Catalog record
| CREATOR | Jihan Ke, Youping Jiang, Zhiyong Cheng, Yulan Zhou, Jiaxu Lu, Bo Xu, Shouquan Yan, Jiafeng Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |