Heart Failure but Not Myocardial Infarction Is Causing Bone Loss in Rodent Models in an FGF23-Independent Manner
Svetlana Slavic, Nejla Latic, Norbert Hassler, Stéphane Blouin, Jochen Zwerina, Reinhold G. Erben · 2025
Read Heart Failure but Not Myocardial Infarction Is Causing Bone Loss in Rodent Models in an FGF23-Independent Manner by Svetlana Slavic, Nejla Latic, Norbert Hassler, Stéphane Blouin, Jochen Zwerina, Reinhold G. Erben (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785340.txt.
Description
Svetlana Slavic and co-authors present a 2025 journal article on whether heart attacks and heart failure directly cause bone loss. Both conditions link to low bone density in patients, but cause was unproven. The team tested three rodent injury models: blocked artery heart attack in mice, brief artery blockage in young and old rats, and pressure-overload heart failure in mice.
Bone density stayed unchanged after heart attack in both rodent setups. The heart failure model, by contrast, cut cortical bone density in the thigh bone. Removing the hormone FGF23 in mutant mice did not rescue the loss. The authors conclude that failure, not infarction, drives the bone effect.
Catalog record
| CREATOR | Svetlana Slavic, Nejla Latic, Norbert Hassler, Stéphane Blouin, Jochen Zwerina, Reinhold G. Erben |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |