Neuromodulatory Effects of Arecoline on Anxiety-like Behavior in Mice Exposed to Chronic Unpredictable Mild Stress
Xiangfei Zhang, Danyang Wang, Jingwen Cui, Bei Fan, Fengzhong Wang, Cong Lu · 2025
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Description
Xiangfei Zhang and co-authors test a betel nut alkaloid against stress-driven anxiety in mice, in a 2025 study. Weeks of unpredictable mild stress left the animals anxious in three standard mazes and open fields. Arecoline treatment restored their exploring: more center time, more light-side time, more open-arm ventures. Stress hormone levels settled back toward normal.
In the hippocampus, key transmitters rebalanced, antioxidant enzymes strengthened, and inflammatory signals cooled. A growth factor and its receptor rose, along with the machinery of synaptic learning. The authors credit a many-front calming: hormone, chemistry, oxidation, and plasticity all nudged together. They present arecoline as a candidate worth careful study for stress disorders.
Catalog record
| CREATOR | Xiangfei Zhang, Danyang Wang, Jingwen Cui, Bei Fan, Fengzhong Wang, Cong Lu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |