Transcranial Sonographic Characteristics of Substantia Nigra in End-Stage Renal Disease Patients with Restless Legs Syndrome: A Diagnostic Marker Study
Caishan Wang, Zhoubing Zhan, Changwei Ding, Yingchun Zhang, Weifeng Luo · 2025
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Description
Caishan Wang, Zhoubing Zhan, Changwei Ding, Yingchun Zhang, and Weifeng Luo test whether an ultrasound scan of one brain area can help diagnose restless legs in kidney patients, in a 2025 paper. Restless legs syndrome, an urge to move the legs that worsens at rest, is common in people whose kidneys have failed. The team scanned 65 dialysis patients, 45 with restless legs and 20 without, plus 30 healthy adults.
The scans measured a dark midbrain structure called the substantia nigra, which is tied to iron and dopamine in the brain. Its bright echo area on the scan was much smaller in patients with restless legs than in either comparison group. A cutoff value sorted the groups with fair accuracy, and a second brain area added little. The authors propose the scan measure as a possible marker for this form of restless legs.
Catalog record
| CREATOR | Caishan Wang, Zhoubing Zhan, Changwei Ding, Yingchun Zhang, Weifeng Luo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |