A Review of ARID1A’s Role in Breast Cancer Progression: Context-Dependent Mechanisms and Therapeutic Implications
Gopalakrishnan Shankari, Dhamodharan Prabhu, Muthusamy Sureshan, Jeyaraman Jeyakanthan, Sundararaj Rajamanikandan · 2025
Read A Review of ARID1A’s Role in Breast Cancer Progression: Context-Dependent Mechanisms and Therapeutic Implications by Gopalakrishnan Shankari, Dhamodharan Prabhu, Muthusamy Sureshan, Jeyaraman Jeyakanthan, Sundararaj Rajamanikandan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785034.txt.
Description
Gopalakrishnan Shankari and co-authors review, in a 2025 paper, the double life of a gene called ARID1A in breast cancer. The gene helps run a complex that repackages DNA and steers which genes are read. In many settings it acts as a brake on tumors, keeping cell division in check and DNA repair working. Lose it, and breast cells grow faster, slip into a more mobile state, and resist treatment.
Yet the same gene can aid tumors when it is overproduced, stirring oxidative stress and early cancer growth. Its loss often travels with an overactive growth pathway and a worse outlook for patients. The authors argue that this split behavior makes the gene valuable: read in context, it can serve as a marker and as a target. Precision care, they suggest, should ask not just whether the gene is altered, but how.
Catalog record
| CREATOR | Gopalakrishnan Shankari, Dhamodharan Prabhu, Muthusamy Sureshan, Jeyaraman Jeyakanthan, Sundararaj Rajamanikandan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |