Multi-Omics Integration Identifies the Cholesterol Metabolic Enzyme DHCR24 as a Key Driver in Breast Cancer
Mingfei Xu, Jinghua Hu, Lulan Pu, Jiayou Liu, Yanhong Yang, Qianqian Li, Jingwen Chen, Shishan Deng, Chaoyue Liu · 2025
Read Multi-Omics Integration Identifies the Cholesterol Metabolic Enzyme DHCR24 as a Key Driver in Breast Cancer by Mingfei Xu, Jinghua Hu, Lulan Pu, Jiayou Liu, Yanhong Yang, Qianqian Li, Jingwen Chen, Shishan Deng, Chaoyue Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12785013.txt.
Description
Mingfei Xu and co-authors identify a cholesterol making enzyme as a driver of breast cancer in a 2025 paper. Faulty cholesterol handling is a known mark of this cancer, but the key molecules were unclear. The team combined genetic evidence, database screens, lab tests, and patient data.
The enzyme, DHCR24, was high in tumors and linked to worse outcomes, above all in two subtypes. Oddly, lowering it in one cell line made those cells act more malignant. The team resolves that puzzle by showing the enzyme acts through the tumor's immune setting rather than through the cancer cells alone. Lowering it also shifted two other genes. They propose the enzyme as a drug target on the cholesterol and immune axis.
Catalog record
| CREATOR | Mingfei Xu, Jinghua Hu, Lulan Pu, Jiayou Liu, Yanhong Yang, Qianqian Li, Jingwen Chen, Shishan Deng, Chaoyue Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |