Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation
Meng Chen, Tianyi Zhang, Sheng Yang, Yiru Niu, Yiling Ge, Zaozao Chen, Juan Zhang, Yuepu Pu, Zhongze Gu, Geyu Liang · 2025
Read Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation by Meng Chen, Tianyi Zhang, Sheng Yang, Yiru Niu, Yiling Ge, Zaozao Chen, Juan Zhang, Yuepu Pu, Zhongze Gu, Geyu Liang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784959.txt.
Description
Meng Chen and colleagues review human heart organoids from construction to drug testing. Their review from twenty twenty-five covers lab-grown miniature hearts. Drug heart toxicity stalls many medicines and endangers patients. Better human-like models could catch toxic drugs earlier.
Stem cell organoids now mimic heart structure and beating function. Three strategies build disease versions of these organoids. Patient cells, gene edits, and environment tweaks each model different illnesses. The review joins building methods with evaluation uses. Changing drug regulations also shape how models get accepted. A single framework links construction, disease modelling, and testing. Pharmaceutical screening may shift from animals toward these models.
Catalog record
| CREATOR | Meng Chen, Tianyi Zhang, Sheng Yang, Yiru Niu, Yiling Ge, Zaozao Chen, Juan Zhang, Yuepu Pu, Zhongze Gu, Geyu Liang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |