Mutated Hif-1αa Proteins with Increased Stability Under Normoxic Conditions Enhance Hypoxia Tolerance of Otomorphs by Promoting Glycolysis and Lactate Shuttle
Xianzong Wang, Junli Yan, Huili Zhai, Jiali Guo, Xueyi Wang, Qing Liu, Shaozhen Liu · 2025
Read Mutated Hif-1αa Proteins with Increased Stability Under Normoxic Conditions Enhance Hypoxia Tolerance of Otomorphs by Promoting Glycolysis and Lactate Shuttle by Xianzong Wang, Junli Yan, Huili Zhai, Jiali Guo, Xueyi Wang, Qing Liu, Shaozhen Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784922.txt.
Description
Seven authors, led by Xianzong Wang, report a gene twist that helps a group of fishes survive low oxygen in this 2025 paper. Fish often face oxygen-poor water, and species differ widely in how well they cope. The trail leads to HIF, a pathway that switches on rescue genes when oxygen drops.
One fish group, the otomorphs, kept two copies of a key HIF gene after an ancient genome doubling. In their main copy, mutations break a signal that normally marks the protein for quick destruction. Computer simulations show the damage blocks the enzyme that reads that signal. The protein thus stays stable even when oxygen is plentiful. The authors link that stability to stronger sugar-burning and lactate shuttling, which fuel cells without oxygen. The finding ties an old duplication to a living survival edge.
Catalog record
| CREATOR | Xianzong Wang, Junli Yan, Huili Zhai, Jiali Guo, Xueyi Wang, Qing Liu, Shaozhen Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |