Mandibular Prognathism in Dolang Sheep: Hi-C Evidence for Localized TAD Remodeling at Craniofacial Loci
Chao Fang, Hang Cao, Lingling Liu, Wujun Liu · 2025
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Description
Chao Fang, Hang Cao, Lingling Liu, and Wujun Liu study a jaw defect in Dolang sheep in a 2025 paper. In this defect the lower jaw sticks out past the upper jaw, the face looks concave, and chewing suffers. It shows up far more often in this flock than is normal, so the team looked for a cause in the genome's three-dimensional shape.
They checked 959 sheep and found the defect in about one in ten. They then built a case-control group of 200 affected and 200 clean sheep. Maps of folded DNA from jaw bone showed the broad fold pattern was much the same in both groups. A few short zones stood out, with more fold borders near genes linked to face growth.
Catalog record
| CREATOR | Chao Fang, Hang Cao, Lingling Liu, Wujun Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |