BRG1 (SMARCA4) Status Dictates the Response to EGFR Inhibitors in Wild-Type EGFR Non-Small Cell Lung Cancer
Rebaz Ahmed, Ranganayaki Muralidharan, Narsireddy Amreddy, Akhil Srivastava, Meghna Mehta, Janani Panneerselvam, Rodrigo Orlandini de Castro, William L. Berry, Susmita Ghosh, Murali Ragothaman, Pawan Acharya, Yan D. Zhao, Roberto Jose Pezza, Anupama Munshi, Rajagopal Ramesh · 2025
Read BRG1 (SMARCA4) Status Dictates the Response to EGFR Inhibitors in Wild-Type EGFR Non-Small Cell Lung Cancer by Rebaz Ahmed, Ranganayaki Muralidharan, Narsireddy Amreddy, Akhil Srivastava, Meghna Mehta, Janani Panneerselvam, Rodrigo Orlandini de Castro, William L. Berry, Susmita Ghosh, Murali Ragothaman, Pawan Acharya, Yan D. Zhao, Roberto Jose Pezza, Anupama Munshi, Rajagopal Ramesh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784900.txt.
Description
Rebaz Ahmed and a large team of co-authors asked in 2025 why some lung cancers resist a common class of targeted drugs. The drugs block a growth signal receptor, and they work best when that receptor is mutated. In cancers where the receptor is normal, results are often weak. The team focused on a gene that helps control which other genes stay active.
Using three lung cancer cell lines and mouse tumors, the group changed the level of that gene and watched drug response shift. Restoring the gene in resistant cells made them sensitive again, in dishes and in mice. Silencing it in other cells pushed them toward resistance. The authors suggest testing patients for this gene to guide drug choice.
Catalog record
| CREATOR | Rebaz Ahmed, Ranganayaki Muralidharan, Narsireddy Amreddy, Akhil Srivastava, Meghna Mehta, Janani Panneerselvam, Rodrigo Orlandini de Castro, William L. Berry, Susmita Ghosh, Murali Ragothaman, Pawan Acharya, Yan D. Zhao, Roberto Jose Pezza, Anupama Munshi, Rajagopal Ramesh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |