Microinflammation-Driven Gene Expression Dynamics in the Pathogenesis of Metabolic Disorders and Cancer
Marian Elisa Gabrielle T. Cadungog, Lemmuel L. Tayo · 2025
Read Microinflammation-Driven Gene Expression Dynamics in the Pathogenesis of Metabolic Disorders and Cancer by Marian Elisa Gabrielle T. Cadungog, Lemmuel L. Tayo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784870.txt.
Description
Marian Cadungog and Lemmuel Tayo hunt for shared gene patterns that link gut trouble, metabolic disease, and cancer through low-grade inflammation. Their 2025 study merges gene expression data from six conditions: irritable bowel syndrome, obesity, type 2 diabetes, and cancers of the colon, kidney, and pancreas.
Network analysis found three gene modules preserved across the diseases. The modules center on RNA processing, spliceosome work, ribosome building, and protein quality control. Hub genes and their microRNA regulators form a web that shapes inflammatory signals from behind the scenes. Classic inflammation pathways were not enriched head-on, which is the twist: the fire may be stoked by the cell's RNA machinery. Systems biologists get a shared driver list across unlike diseases.
Catalog record
| CREATOR | Marian Elisa Gabrielle T. Cadungog, Lemmuel L. Tayo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |