Systematic Exploration of Molecular Mechanisms and Natural Herbal Therapeutic Strategies for Cancer Cachexia
Pengyu Han, Xingyu Zhou, Guomin Dong, Litian Ma, Xiao Han, Donghu Liu, Jin Zheng, Jin Zhang · 2025
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Description
Eight researchers review herbal strategies for cancer cachexia in a paper from 2025. Cachexia is a wasting syndrome in advanced cancer, marked by inflammation, lost appetite, and shrinking muscle and fat. Standard drugs help little and can cause harm. The review maps the syndrome's molecular drivers across the brain, fat, gut, immune system, and muscle.
Several herbs show anti-inflammatory and muscle-sparing effects in early studies. Examples include astragalus and a skullcap species, which calm key inflammatory signals. Treated animals kept more muscle and ate better, though tumors were barely affected. Most evidence is still preclinical. The authors call for careful translation into human trials.
Catalog record
| CREATOR | Pengyu Han, Xingyu Zhou, Guomin Dong, Litian Ma, Xiao Han, Donghu Liu, Jin Zheng, Jin Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |