Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing
Zheqi Lou, Xianyan Zeng, Tinghui Jiang, Peizhen Du, Jiyao Rao, Xinyan Dai, Haishuang Lin, Yong Zhu · 2025
Read Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing by Zheqi Lou, Xianyan Zeng, Tinghui Jiang, Peizhen Du, Jiyao Rao, Xinyan Dai, Haishuang Lin, Yong Zhu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784838.txt.
Description
Zheqi Lou and seven co-authors report a 2025 study on how human stem cells change the ends of their gene messages as they turn into nerve cells. This end choice, called alternative polyadenylation, can lengthen or shorten a message and change how it is used. Past work relied on short-read gene scans, which gave only a partial view of these changes.
The team paired long-read scans with short-read scans to map the full picture in early nerve growth. They found more than twenty thousand new message forms and over eight thousand new end sites that had not been marked before. Distinct patterns emerged at each stage, and one gene stood out as a key target of this control. The results widen the known map of message ends and show how this layer of control helps steer cell fate.
Catalog record
| CREATOR | Zheqi Lou, Xianyan Zeng, Tinghui Jiang, Peizhen Du, Jiyao Rao, Xinyan Dai, Haishuang Lin, Yong Zhu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |