Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities
Peng Chen, Junhao Chen, Peiqin Zhan, Xinni Ye, Li Zhao, Zhongsong Zhang, Jieming Zuo, Hongjin Shi, Xiangyun Li, Songhong Wu, Yuanzhi Fu, Haifeng Wang, Shi Fu · 2025
Read Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities by Peng Chen, Junhao Chen, Peiqin Zhan, Xinni Ye, Li Zhao, Zhongsong Zhang, Jieming Zuo, Hongjin Shi, Xiangyun Li, Songhong Wu, Yuanzhi Fu, Haifeng Wang, Shi Fu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784818.txt.
Description
Chen and co-authors review efforts to target support cells that surround prostate tumors. Advanced prostate cancer, in particular the castration-resistant form, remains hard to treat. The tumor setting shuts out immune attack and blunts therapy. Fibroblasts tied to the cancer shape talk between tumor and its support tissue. Yet these cells vary widely and shift form, which muddies sorting them. Wiping them out wholesale may fail or even backfire.
The review covers where these fibroblasts come from and what subtypes do. It tracks how they drive growth and drug resistance. New treatment angles that aim at fibroblasts get close attention. Careful targeting, not broad removal, is the theme.
Catalog record
| CREATOR | Peng Chen, Junhao Chen, Peiqin Zhan, Xinni Ye, Li Zhao, Zhongsong Zhang, Jieming Zuo, Hongjin Shi, Xiangyun Li, Songhong Wu, Yuanzhi Fu, Haifeng Wang, Shi Fu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |