Outcomes Following Radiotherapy for Oligoprogressive NSCLC on Immune Checkpoint Inhibitors: A Real-World, Multinational Experience
Umair Mahmood, Eleni Josephides, Nicholas Coupe, Daniel Smith, Shahreen Ahmad, Omar Al-Salihi, Sze M. Mak, Meenali Chitnis, Alexandros Georgiou, Daniel Ajzensztejn, Eleni Karapanagiotou, Geoff S. Higgins, Niki Panakis, Jonathan D. Schoenfeld, Michael Skwarski · 2025
Read Outcomes Following Radiotherapy for Oligoprogressive NSCLC on Immune Checkpoint Inhibitors: A Real-World, Multinational Experience by Umair Mahmood, Eleni Josephides, Nicholas Coupe, Daniel Smith, Shahreen Ahmad, Omar Al-Salihi, Sze M. Mak, Meenali Chitnis, Alexandros Georgiou, Daniel Ajzensztejn, Eleni Karapanagiotou, Geoff S. Higgins, Niki Panakis, Jonathan D. Schoenfeld, Michael Skwarski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784812.txt.
Description
Umair Mahmood and co-authors gather the largest multinational record yet of radiation used when lung cancer creeps forward during immunotherapy. Some patients on checkpoint inhibitors progress in only a few spots while the rest of the disease stays controlled. Zapping those few lesions may extend the drug's benefit, a strategy called treating oligoprogression.
Centers identified patients irradiated on five or fewer growing lesions while on immunotherapy, from 2010 to 2023. Of nearly twelve hundred treated patients, about one hundred met the study's rules. The team models local control and survival to find who gains most. Real-world pooling across countries gives this young strategy its firmest footing yet.
Catalog record
| CREATOR | Umair Mahmood, Eleni Josephides, Nicholas Coupe, Daniel Smith, Shahreen Ahmad, Omar Al-Salihi, Sze M. Mak, Meenali Chitnis, Alexandros Georgiou, Daniel Ajzensztejn, Eleni Karapanagiotou, Geoff S. Higgins, Niki Panakis, Jonathan D. Schoenfeld, Michael Skwarski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |