Epstein-Barr virus infection shapes the genetic, transcriptomic, and immune microenvironment landscape of Burkitt lymphoma
Qing Xiao, Yilei Zhang, Zhongyi Chen, Xinrong Liu, Wentao Yu, Tiansheng Wang, Ling Chu · 2025
Read Epstein-Barr virus infection shapes the genetic, transcriptomic, and immune microenvironment landscape of Burkitt lymphoma by Qing Xiao, Yilei Zhang, Zhongyi Chen, Xinrong Liu, Wentao Yu, Tiansheng Wang, Ling Chu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784524.txt.
Description
Qing Xiao and co-authors study how Epstein-Barr virus infection shapes Burkitt lymphoma at the genetic, transcriptomic, and immune levels. Their 2025 paper deals with a highly aggressive B-cell lymphoma whose course is closely tied to virus status.
Targeted sequencing of a large gene panel covered 27 cases, and RNA analyses covered 25. Virus-negative tumors had more chromosomal amplifications at several sites, and novel variants in one gene in adults. Virus-positive tumors were enriched for mutations in a different gene. More than sixteen hundred genes differed in expression between the groups, mostly in key growth pathways. The landscape differs sharply by virus status.
Catalog record
| CREATOR | Qing Xiao, Yilei Zhang, Zhongyi Chen, Xinrong Liu, Wentao Yu, Tiansheng Wang, Ling Chu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |