Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis
Karmenia Jessica Kurnia Niaga, Fransiskus Xaverius Rinaldi, Nathania Nathania, Pedro Arruda Supinto, Stevan Kristian Lionardi, Rivan Yo, Agoes Wilyono, Parningotan Yosi Silalahi · 2025
Read Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis by Karmenia Jessica Kurnia Niaga, Fransiskus Xaverius Rinaldi, Nathania Nathania, Pedro Arruda Supinto, Stevan Kristian Lionardi, Rivan Yo, Agoes Wilyono, Parningotan Yosi Silalahi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784055.txt.
Description
Karmenia Jessica Kurnia Niaga and co-authors wrote this 2025 network meta-analysis on two drug groups used for an enlarged prostate and their possible link to dementia. Alpha-blockers and a second group that shrinks the gland both help urinary symptoms, but worry has grown that they might raise dementia risk. Past studies disagree, so the team pooled the proof in a network that compares several drugs at once.
Five large studies with more than 3.6 million patients, of low bias risk, met the rules for the pool. The pooled result found no clear rise in dementia risk for either drug group versus no treatment. Ranking scores did hint that the gland-shrinking drugs carried a somewhat higher chance than the others. The authors call for care in reading that hint, since the main test showed no firm link.
Catalog record
| CREATOR | Karmenia Jessica Kurnia Niaga, Fransiskus Xaverius Rinaldi, Nathania Nathania, Pedro Arruda Supinto, Stevan Kristian Lionardi, Rivan Yo, Agoes Wilyono, Parningotan Yosi Silalahi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |