Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum
Chuanfu Li, Jiang Jiang, Shuangshuang Tu, Yijun Dong, Wenzhi Zhang, Xi Chen · 2025
Read Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum by Chuanfu Li, Jiang Jiang, Shuangshuang Tu, Yijun Dong, Wenzhi Zhang, Xi Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784022.txt.
Description
Chuanfu Li and five co-authors study how disc decay in the spine may be driven by a fat-based cell death. Their paper is from two thousand twenty-five. The soft core of a disc, the nucleus pulposus, loses health as the disc decays. A lipid enzyme called LPCAT1 and its product guard the walls of cell sacs called lysosomes, they find.
Scans of worn human tissue show this guard is low in decay. With less of it, sac walls leak and cells die by ferroptosis, an iron-linked death. Raising the enzyme adds touch points between two cell parts, moves lipids, and mends the sac walls. Cell death then falls. The path may be a drug target.
Catalog record
| CREATOR | Chuanfu Li, Jiang Jiang, Shuangshuang Tu, Yijun Dong, Wenzhi Zhang, Xi Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |