Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study
Ji-Won Kwon, Seong-Hwan Moon, Kyung-Soo Suk, Si Young Park, Hak-Sun Kim, Sub-Ri Park, Namhoo Kim, Byung Ho Lee · 2025
Read Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study by Ji-Won Kwon, Seong-Hwan Moon, Kyung-Soo Suk, Si Young Park, Hak-Sun Kim, Sub-Ri Park, Namhoo Kim, Byung Ho Lee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784019.txt.
Description
Ji-Won Kwon and seven co-authors test whether a bone building drug helps screws grip in osteoporotic rabbit bone, in this 2025 study. Steroid induced bone loss makes implant fixation unreliable, a real problem in spine surgery. Fifty-five rabbits received screws in the hip bone, then three weeks of one of several treatments or none.
The drug romosozumab, which blocks a bone brake protein, won clearly. Bone grew onto the screw surface more, filled the surrounding space more, and held against pulling far harder than with parathyroid hormone, its combination rival, or no treatment. Microscopy showed fresh, well organized bone around the implants. The authors suggest the drug as support therapy for implant surgery in patients whose bones are thinned by steroids or disease.
Catalog record
| CREATOR | Ji-Won Kwon, Seong-Hwan Moon, Kyung-Soo Suk, Si Young Park, Hak-Sun Kim, Sub-Ri Park, Namhoo Kim, Byung Ho Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |