Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory Axis
Xi Chen, Jiang Jiang, Yijun Dong, Shuangshuang Tu, Chuanfu Li, Wenzhi Zhang, Yongjin Li, Jun Hu · 2025
Read Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory Axis by Xi Chen, Jiang Jiang, Yijun Dong, Shuangshuang Tu, Chuanfu Li, Wenzhi Zhang, Yongjin Li, Jun Hu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12784016.txt.
Description
Xi Chen and co-authors study back pain from worn spinal discs in a paper published in 2025. They ask whether a fat signal seen on a special scan of the disc can mark patients who hurt more. They also probe what that signal means inside the disc tissue, using several lab methods at once.
Patients whose scans showed a strong fat peak reported worse back pain and higher disability scores before surgery. Lab tests on disc cells from that group found stored fat droplets and an active swelling pathway tied to a signal called IL-17. Pain scores rose along with the level of that signal and the amount of fat. The authors suggest the scan peak could serve as a marker for pain, and that fat buildup may help drive the pain.
Catalog record
| CREATOR | Xi Chen, Jiang Jiang, Yijun Dong, Shuangshuang Tu, Chuanfu Li, Wenzhi Zhang, Yongjin Li, Jun Hu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |