The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors
Obinna C Ubah, Eric W Lake, Kendahl L Ott, Stella Priyanka, Sasha Celeda, Jayden L West, Gihan S Gunaratne, Ke Shi, Nicholas H Moeller, Andrew J Porter, Hideki Aihara, David Kosoff, Aaron M LeBeau, Caroline J Barelle · 2025
Read The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors by Obinna C Ubah, Eric W Lake, Kendahl L Ott, Stella Priyanka, Sasha Celeda, Jayden L West, Gihan S Gunaratne, Ke Shi, Nicholas H Moeller, Andrew J Porter, Hideki Aihara, David Kosoff, Aaron M LeBeau, Caroline J Barelle (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783797.txt.
Description
Thirteen authors reveal how shark derived binders block a key inflammation signal in this 2025 study. The signal, TNF-alpha, drives many immune diseases, and all current drugs against it also bind its membrane form, which can trigger reverse signals that suppress immunity and invite infection.
The team solved crystal structures of two shark variable antigen receptors bound to the soluble form of the signal, at two distinct sites. One binder grips a site found only on the soluble form, so it spares the membrane form. In activated T cells, the binders caused no reverse signaling, unlike current drugs. A selective blocker could be safer for high risk patients.
Catalog record
| CREATOR | Obinna C Ubah, Eric W Lake, Kendahl L Ott, Stella Priyanka, Sasha Celeda, Jayden L West, Gihan S Gunaratne, Ke Shi, Nicholas H Moeller, Andrew J Porter, Hideki Aihara, David Kosoff, Aaron M LeBeau, Caroline J Barelle |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |