Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression
Toshiharu kamishikiryo, Eri itai, Yuki mitsuyama, Yoshikazu masuda, Osamu yamamoto, Tatsuji tamura, Hiroaki jitsuiki, Akio mantani, Norio yokota, Go okada · 2025
Read Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression by Toshiharu kamishikiryo, Eri itai, Yuki mitsuyama, Yoshikazu masuda, Osamu yamamoto, Tatsuji tamura, Hiroaki jitsuiki, Akio mantani, Norio yokota, Go okada (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783789.txt.
Description
Toshiharu Kamishikiryo and co-authors studied how the size of the hippocampus relates to response to an antidepressant in depression, in a 2025 paper. The hippocampus shapes memory and emotion, and the drug escitalopram can grow new cells in one of its zones. The team asked whether its size before and after treatment marks who improves.
They studied 107 patients with moderate to severe depression, with follow-up for 71 of them. At the start, responders had a larger left hippocampus and a stronger leftward tilt than nonresponders. After treatment, the right hippocampus and its head grew in volume. The authors weigh these shifts as possible guides for care.
Catalog record
| CREATOR | Toshiharu kamishikiryo, Eri itai, Yuki mitsuyama, Yoshikazu masuda, Osamu yamamoto, Tatsuji tamura, Hiroaki jitsuiki, Akio mantani, Norio yokota, Go okada |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |