Neural mechanisms of the V2M–PrL pathway mediate blue light-induced spatial memory impairment
Yuan Zhang, Guang’an Tong, Weipeng Wang, Yaoyang Xu, Wenbo Zhang, Xiangmin Chen, Xuejie Wang, Qi Xu, Caihong Han, Liecheng Wang, Shijun Weng, Pingping Zhang · 2025
Read Neural mechanisms of the V2M–PrL pathway mediate blue light-induced spatial memory impairment by Yuan Zhang, Guang’an Tong, Weipeng Wang, Yaoyang Xu, Wenbo Zhang, Xiangmin Chen, Xuejie Wang, Qi Xu, Caihong Han, Liecheng Wang, Shijun Weng, Pingping Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783663.txt.
Description
Twelve researchers trace a brain circuit behind blue light harming memory in mice, in a paper from 2025. Blue light had been shown to weaken spatial memory, which animals use to recall places. The team focused on a path from a visual area of the brain to a frontal area. Using virus tracing and light-based recordings, they mapped how the path's cells connect and fire.
The path runs from excitatory visual cells to calming cells in the frontal area, which then quiet its excitatory cells. Removing the visual cells erased the blue light effect. Switching the circuit on copied the harm, and switching it off reversed it. The findings name a clear target for later work.
Catalog record
| CREATOR | Yuan Zhang, Guang’an Tong, Weipeng Wang, Yaoyang Xu, Wenbo Zhang, Xiangmin Chen, Xuejie Wang, Qi Xu, Caihong Han, Liecheng Wang, Shijun Weng, Pingping Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |